The Journal of Analytical Toxicology

Concentration Distribution of the Marijuana Metabolite Δ9-Tetrahydrocannabinol-9-Carboxylic Acid and the Cocaine Metabolite Benzoylecgonine inQuantitative Analysis of the Aminosteroidal Non-Depolarizing Neuromuscular Blocking Agent Vecuronium by LC-ESI-MS: A Postmortem Investigation

The Detection and Quantitative Analysis of the Psychoactive Component of Salvia divinorum, Salvinorin A, in Human Biological Fluids Using Liquid Chromato

The Detection and Quantitative Analysis of the Psychoactive Component of Salvia divinorum, Salvinorin A, in Human Biological Fluids Using Liquid Chromato

Issue Date: July/August 2008
Volume Number: 32
Issue Number: 6
Page Numbers: 417–421
Authors: Pamela C. McDonough, Justin M. Holler, Shawn P. Vorce, Thomas Z. Bosy, Joseph Magluilo, Jr., and Marilyn R. Past
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Pamela C. McDonough1, Justin M. Holler1, Shawn P. Vorce1, Thomas Z. Bosy2, Joseph Magluilo, Jr.1, and Marilyn R. Past1
1Division of Forensic Toxicology, The Armed Forces Medical Examiner System, Armed Forces Institute of Pathology, 1413 Research Boulevard, Building 102, Rockville, Maryland 20850-3125, and 2Navy Drug Screening Laboratory, Bldg. H2033, Naval Air Station, Jacksonville, Florida 32212

Salvia divinorum, a member of the mint plant family, has hallucinogenic properties that have become increasingly sought after by recreational drug users. The main psychoactive component, salvinorin A, has potency comparable to lysergic acid diethylamide. Though still legal to possess in most of the United States and much of Europe, little is known regarding the compound's long-term health effects, addiction liability, and pharmacokinetics. Limited data are available in the scientific literature, and few analytical methods are published for the detection in human biological fluids. These factors contribute to the unfamiliarity of the compound and complicate the method development process necessary to accommodate special requested testing for salvinorin A. A sensitive analytical method for the detection and quantitation of salvinorin A in human biological fluids was developed and validated to resolve analytical shortcomings. The method utilizes a solid-phase extraction technique coupled with liquid chromatography-electrospray ionization mass spectrometry operated in selected ion monitoring mode. The assay has a linear range of 5.0–100 ng/mL with a correlation coefficient of 0.997. The limit of detection and limit of quantitation were experimentally determined as 2.5 and 5.0 ng/mL, respectively. The method has been applied to blood and urine samples successfully and can be used to detect the presence of salvinorin A in forensic testing.

Journal of Analytical Toxicology, July/August 2008, Volume 32, Number 6, pages 417–421.

Reproduction (photocopying) of editorial content without publisher's permission is prohibited.


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The Journal of Analytical Toxicology Articles The Detection and Quantitative Analysis of the Psychoactive Component of Salvia divinorum, Salvinorin A, in Human Biological Fluids Using Liquid Chromato

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