| A Validated Method for Simultaneous Screening and Quantification of Twenty-Three Benzodiazepines and Metabolites Plus Zopiclone and Zaleplone in Whole Blood by Liquid–Liquid Extraction and Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry |
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An ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS–MS) method for detection of 23 benzodiazepines and related compounds in whole blood was developed and validated. |
| Correlations Between Phthalate Metabolites in Urine, Serum, and Seminal Plasma from Young Danish Men Determined by Isotope Dilution Liquid Chromatography Tandem Mass Spectrometry |
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Phthalates are suspected of endocrine disrupting effects. We aimed to develop an analytical method for simultaneous determination of several phthalate metabolites in human urine, serum, and seminal plasma and to study correlations between levels of metabo |
| Urinary Concentrations of Gamma-Hydroxybutyric Acid and Related Compounds in Pregnancy |
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Endogenous production complicates the interpretation when gamma-hydroxybutyric acid (GHB) is measured in urine for forensic purposes. We performed a cross-sectional study to test the hypothesis that pregnant women have higher levels of urinary GHB than no |
| Uptake and Distribution of the Abused Inhalant 1,1-Difluoroethane in the Rat |
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1,1-Difluoroethane (DFE) is a halogenated hydrocarbon used as a propellant in products designed for dusting electronic equipment and air brush painting. When abused, inhaled DFE produces intoxication and loss of muscular coordination. To investigate DFE t |
| Stability of the Tobacco-Specific Nitrosamine 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol (NNAL) in Urine Samples Stored at Various Temperatures |
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Urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and NNAL-glucuronide, which are metabolites of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), are valuable biomarkers of tobacco exposure. |
| Identification and Quantification of Nicotine Biomarkers in Human Oral Fluid from Individuals Receiving Low-Dose Transdermal Nicotine: A Preliminary Study |
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The objective of this preliminary study was to identify and quantify potential nicotine (NIC) biomarkers in post-exposure oral fluid samples collected from 10 NIC-abstinent human participants administered 7 mg transdermal NIC using liquid chromatography–t |
| Short Communication: The Prevalence of Alcohol and Drugs in Sampled Oral Fluid is Related to Sample Volume |
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About 22,000 samples of oral fluid have been collected in five population studies in Norway using either the Intercept® or Statsure™ oral fluid sampling devices. The prevalence of alcohol and drugs was found to be higher in oral fluid samples with small v |
| A Simple and Sensitive Method for the Determination of Propofol in Human Solid Tissues by Gas Chromatography–Mass Spectrometry |
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Propofol is a widely used intravenous agent for induction and maintenance of anesthesia and for sedation in intensive care patients, but it is also associated with abuse and dependency. A simple and sensitive method for the determination of propofol in hu |
| Technical Note: Comparison of Ethanol and Other Drugs-of-Abuse Concentrations in Whole Blood Stored in Venoject® Glass and Plastic and in Venosafe™ Plastic Evacuated Tubes |
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The aim of this study was to evaluate the stability of blood concentrations of a variety of illegal and medicinal drugs that are important for forensic analyses when spiked and stored in Vacutainer® or Venosafe evacuated plastic collection tubes compared |
| Screening and Quantitative Determination of Twelve Acidic and Neutral Pharmaceuticals in Whole Blood by Liquid–Liquid Extraction and Liquid Chromatography–Tandem Mass Spectrometry |
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We describe a multi-method for simultaneous identification and quantification of 12 acidic and neutral compounds in whole blood. The method involves a simple liquid–liquid extraction, and the identification and quantification are performed using liquid ch |
| Quantification of Methadone and its Metabolite 2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine in Third Instar Larvae of Lucilia sericata (Diptera: Calliphoridae) Using Liquid Chromatography–Tandem Mass Spectrometry |
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Entomotoxicology studies the application of toxicological analysis on necrophageous insects present on human remains. This paper describes the development and validation of a sensitive liquid chromatography–tandem mass spectrometry method for quantificati |
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| Letter to the Editor: 3,3'-Dichlorobenzidine |
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I have recently read an article entitled "Development and Evaluation of a Microliter Plate Enzyme Immunoassay for Antibodies to 3,3'-Dichiorobenzidine" published in the Journal of Analytical Toxicology, Volume 11, January/February 1987. The introduction o |
| Letter to the Editor: Hair Analysis for Cocaine Continues to be a Valuable Tool in Forensic and Clinical Toxicology |
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To the Editor: |
| Analysis of 4-Aminobiphenyl Hemoglobin Adducts in Smokers and Nonsmokers by Pseudo Capillary On-Column Gas Chromatography–Tandem Mass Spectrometry |
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We describe here a hemoglobin adduct assay applied to an analysis of samples from smokers and nonsmokers. The assay includes a sensitive method for quantification of orthotoluidine 2-aminonaphthylene, and 3- and 4-aminobiphenyl hemoglobin adducts in human |
| Quantification of Blood Betel Quid Alkaloids and Urinary 8-Hydroxydeoxyguanosine in Humans and their Association with Betel Chewing Habits |
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Chewing betel quid is a common habit in Taiwan and associated with the risk of oral cancer. Betel quid contains arecoline and arecaidine, which may serve as the exposure biomarkers of a chewing habit. We developed a liquid chromatography–tandem mass spect |
| Vitreous Humor as an Alternative Matrix for Comprehensive Drug Screening in Postmortem Toxicology by Liquid Chromatography–Time-of-Flight Mass Spectrometry |
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Liquid chromatography–time-of-flight mass spectrometry (LC–TOFMS) is an emerging technique in toxicological drug screening. The applicability of vitreous humor as an alternative matrix for drug screening by LC–TOFMS in postmortem investigations was studie |
| Ethyl Glucuronide Concentrations in Oral Fluid, Blood, and Urine After Volunteers Drank 0.5 and 1.0 g/kg Doses of Ethanol |
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The aim of this study was to investigate the concentrations of ethyl glucuronide (EtG) in oral fluid, blood, and urine after healthy volunteers drank two doses of ethanol, 0.5 (n = 11) and 1.0 g/kg (n = 10), after an overnight fast. Samples of oral fluid, |
| Validation of an Extraction and Gas Chromatography–Mass Spectrometry Quantification Method for Cocaine, Methadone, and Morphine in Postmortem Adipose Tissue |
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Adipose tissue is a complex biological matrix that necessitates several pre-analytical preparation steps to separate drugs and metabolites from the lipophilic matrix. A novel, sensitive, and specific gas chromatographic–mass spectrometric (GC–MS) method f |
| Development of a Method for the Determination of Bisphenol A at Trace Concentrations in Human Blood and Urine and Elucidation of Factors Influencing Method Accuracy and Sensitivity |
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Bisphenol A (BPA) is an industrial chemical used to make polymers including some used in food contact applications. Virtually complete presystemic clearance of orally administered BPA occurs in humans by metabolism to BPA-glucuronide
(BPA-G), but some bi |