The Journal of Analytical Toxicology



Letter to the Editor: Time of Heroin Use

Letter to the Editor: Time of Heroin Use

Issue Date: July/August 2008
Volume Number: 32
Issue Number: 6
Page Numbers: 454–456
Authors: Amanda J. Jenkins and Edward J. Cone
Price (Article): $40.00
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Amanda J. Jenkins1 and Edward J. Cone2
1The Office of the Cuyahoga County Coroner, Cleveland, Ohio and 2ConeChem Research, Severna Park, Maryland

We encountered a case of fatal congestive heart failure that occurred under the influence of flecainide. In this case, an extreme postmortem increase in the flecainide level was identified in cardiac blood. The patient had been administered 400 mg/day of flecainide for seven days before death. Antemortem plasma obtained 13 h before death showed a flecainide concentration of 2.5 mg/L and a pH of 7.4. In comparison, centrifuged supernatants of postmortem right and left cardiac blood contained flecainide concentrations of 13.8 and 44.2 mg/L, respectively, with pH of 5.5 in both samples. This increase in blood flecainide concentration was attributed to postmortem redistribution, as about 18 h had passed between the last intake of flecainide and death.

Journal of Analytical Toxicology, July/August 2008, Volume 32, Number 6, pages 454–456.

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