The Journal of Analytical Toxicology

Case Report: Detection of Clenbuterol in Heroin Users in Twelve Postmortem Cases at the Philadelphia Medical Examiner’s OfficeUrine Monitoring of Diazepam Abuse—New Intake or Not?

Drug Testing in Oral Fluid—Evaluation of Sample Collection Devices

Drug Testing in Oral Fluid—Evaluation of Sample Collection Devices

Issue Date: July/August 2008
Volume Number: 32
Issue Number: 6
Page Numbers: 393–401
Authors: Kaarina Langel, Charlotta Engblom, Anna Pehrsson, Teemu Gunnar, Kari Ariniemi, and Pirjo Lillsunde
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Kaarina Langel, Charlotta Engblom, Anna Pehrsson, Teemu Gunnar, Kari Ariniemi, and Pirjo Lillsunde
National Public Health Institute, Drug Research Unit, Mannerheimintie 166, Helsinki 00300, Finland

Nine different oral fluid (OF) collection devices were studied to evaluate their suitability for collecting samples for drug analysis. The devices were Greiner Bio-One, Orasure Intercept®, Immunalysis Quantisal™, StatSure Saliva·Sampler™, Cozart®, Sarstedt Salivette®, Malvern Medical OraCol, Acro Biotech Salicule, and Varian OraTube™. For comparison, OF was also collected into plastic tubes. The volume of collected OF was quantified for samples collected both in vitro and from volunteers. Drug recovery was studied by collecting OF fortified at 1000 ng/mL with amphetamine, 3,4-methylenedioxymethamphetamine, cocaine, Δ9-tetrahydrocannabinol, morphine, codeine, diazepam, and alprazolam with the devices in vitro and analyzing the samples with gas chromatography—mass spectrometry. Recovery of ethanol was measured from 0.2% in OF by headspace gas chromatography—flame-ionization detection. The stability of drugs in the samples was studied by analyzing the samples after 0, 14, and 28 days storage. The study shows that there are substantial differences between the OF collection devices on the market. Some are well suited for collecting samples for toxicological analysis, but some give quite poor results.

Journal of Analytical Toxicology, July/August 2008, Volume 32, Number 6, pages 393–401.

Reproduction (photocopying) of editorial content without publisher's permission is prohibited.


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