The Journal of Analytical Toxicology

Technical Note: Detection of 1-Benzylpiperazine and 1-(3-Trifluoromethylphenyl)-piperazine in Urine Analysis Specimens Using GC-MS and LC-ESI-MSLetter to the Editor: Time of Heroin Use

Case Report: Postmortem Increase of Flecainide Level in Cardiac Blood

Case Report: Postmortem Increase of Flecainide Level in Cardiac Blood

Issue Date: July/August 2008
Volume Number: 32
Issue Number: 6
Page Numbers: 451–453
Authors: Kei Yoshitome, Satoru Miyaishi, Yuji Yamamoto, and Hideo Ishizu
Price (Article): $40.00
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Kei Yoshitome1, Satoru Miyaishi1, Yuji Yamamoto1, and Hideo Ishizu2
1Department of Legal Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan and 2Department of Social Work, Faculty of Health and Welfare, Kawasaki University of Medical Welfare, Okayama, Japan

We encountered a case of fatal congestive heart failure that occurred under the influence of flecainide. In this case, an extreme postmortem increase in the flecainide level was identified in cardiac blood. The patient had been administered 400 mg/day of flecainide for seven days before death. Antemortem plasma obtained 13 h before death showed a flecainide concentration of 2.5 mg/L and a pH of 7.4. In comparison, centrifuged supernatants of postmortem right and left cardiac blood contained flecainide concentrations of 13.8 and 44.2 mg/L, respectively, with pH of 5.5 in both samples. This increase in blood flecainide concentration was attributed to postmortem redistribution, as about 18 h had passed between the last intake of flecainide and death.

Journal of Analytical Toxicology, July/August 2008, Volume 32, Number 6, pages 451–453.

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The Journal of Analytical Toxicology Articles Case Report: Postmortem Increase of Flecainide Level in Cardiac Blood

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