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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 32, Number 4, May,
pp.324-326
CASE REPORT:
A Fatality Involving 1,3-Propanediol and its Implications in Measurement
of other Glycols
Uttam Garg1, C. Clinton Frazee, III1, Mike Kiscoan1, David Scott1,
Bonita Peterson2, and David Cathcart2
1Department of Pathology and Laboratory Medicine, Children’s
Mercy Hospitals and Clinics, and University of Missouri– School
of Medicine, Kansas City, Missouri and
2Buchanan County Medical
Examiner’s Office, St. Joseph, Missouri
The decomposed body of a 45-year-old female was
found, face down, in a mobile home, along with a suicide note
and two antifreeze containers. Analysis of the body fluid collected
from the decedent showed the presence of 58 mg/dL ethanol, but
suspected ethylene glycol was not found in the sample. However,
an unusually large peak of internal standard, 1,3-propanediol,
was found in the sample. Gas chromatography–mass spectrometry
analysis confirmed the presence of 1,3-propanediol in the sample.
Using gas chromatography–flame-ionization detection, the
concentration of 1,3-propanediol was determined to be 445 mg/dL.
To our knowledge, this is the first report involving 1,3-propanediol
as the cause of death. The study also highlights the importance
for the close scrutiny of data, as 1,3-propanediol is a frequently
used internal standard for the assay of glycols.
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