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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 30, Number 8, October 2006,
pp.581-592
Performance Evaluation of Thermal Desorption System (TDS)
for Detection of Basic Drugs in Forensic Samples by GC–MS
Joseph A. Crifasi[1], Michael F. Bruder[1], Christopher W. Long[1], and
Kimberly Janssen[2]
[1]Saint Louis University Forensic Toxicology Laboratory, St. Louis, Missouri
and
[2]Saint Louis University Clinical Laboratory Science Program, St. Louis, Missouri
Stir bar sorptive extraction is an innovative sample extraction
technique that can be used to process blood, urine, and tissue samples for routine
drug screening in the forensic toxicology laboratory. The Gerstel Twister™
desorption unit (TDU) system is a multifunctional desorption unit capable of
determining the presence of analytes from liquid samples after extraction using
the Twister stir bar. The TDU desorption system was evaluated for use in combination
with gas chromatography–mass spectrometry (GC–MS) for determining
the presence of basic drugs in forensic samples. Human blood fortified with
known quantities of drugs was used to evaluate sample diluents, extraction time,
injection parameters and recovery. Case specimens containing drugs typically
encountered in forensic samples were evaluated using the desorption method and
compared with a liquid–liquid extraction method followed by GC–MS
analysis. This evaluation demonstrated that the TDU desorptive method worked
equally as well as the routine extraction method for the detection of basic
drugs in screening forensic samples. In addition, the described technique avoids
the use of extraction solvents and the subsequent centrifugation, transfer,
and concentration steps required of liquid–liquid and solid-phase extraction
methods.
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