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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 30, Number 8, October 2006,
pp.551-553
Occupational Exposure to Methamphetamine in Workers Preparing
Training Aids for Drug Detection Dogs
P.R. Stout[1], C.K. Horn[2], K.L. Klette[3], and J. Given[4],
[1]Center for Forensic Sciences, Research Triangle Park, North Carolina;
[2]Navy Drug Screening Laboratory, Jacksonville, Florida;
[3]Navy Drug Screening Laboratory, Great Lakes, Illinois; and
[4]Naval Criminal Investigative Service Regional Forensic Laboratory, Norfolk,
Virginia
As a part of ongoing testing of personnel preparing training aids
for drug detection dogs at the Naval Criminal Investigative Service Regional
Forensic Laboratory, personnel handling methamphetamine (MTH) were subject to
voluntary urine drug testing. This provided a model of potential unwitting or
environmental exposure contribution to MTH concentrations in urine. Urine samples
were collected from multiple individuals on the day before, the day of, and
the day after the individuals had handled up to 500-g quantities of MTH during
the assembly of training aids. Personnel wore gloves, dust masks, and lab coats
during the preparation of training aids. A total of 101 urine samples were analyzed
for the presence of MTH and amphetamine (AMP) by gas chromatography–mass
spectrometry after solid-phase extraction and derivatization. Urine samples
collected during and after personnel handled drug yielded a mean MTH concentration
of 48 ng/mL with a maximum concentration of 262 ng/mL and a minimum detected
concentration of approximately 1.6 ng/mL. Thirty-five of the 52 post drug-handling
samples had detectable MTH. Ten of the samples had MTH concentrations above
the method limit of quantitation of 15 ng/mL. Only one sample had a concentration
greater than 50 ng/mL. None of the samples had detectable AMP. From this limited
study, it was evident that handling of MTH under these conditions resulted in
minimal exposure and small but detectable concentrations of MTH in urine.
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