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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 24,
Number 8, November/December,
pp. 715-717
GC–MS Analysis
of the Total Æ9-THC Content of Both Drug- and Fiber-Type Cannabis Seeds
Samir A.
Ross1,2, Zlatko Mehmedic1, Timothy P. Murphy4, and Mahmoud A. ElSohly1,3,4
1National Center for Natural Products Research, Research Institute of Pharmaceutical
Sciences; Departments of Pharmacognosy2 and Pharmaceutics3, School of Pharmacy,
University of Mississippi, University, MS 38677 and 4ElSohly Laboratories, Incorporated
(ELI), 5 Industrial Park Drive, Oxford, MS 38655
A GC–MS method was performed to determine the total Æ9-THC content in both
drug- and fiber-type cannabis seeds. Drug-type seeds were found to contain much
higher levels of Æ9-THC (35.6–124 µg/g) than fiber (hemp) seeds (0–12
µg/g). The majority of Æ9-THC was found to be located on the surface of
the seeds. Approximately 90% of the total Æ9-THC was removed by a simple, quick
wash with chloroform. Washed drug-type seeds contained less than 10 µg/g.
Separation of the seeds into the kernel and testa showed that the bulk of Æ9-THC
is located in the testa, mainly on the outside. The kernels of drug- and fiber-type
cannabis seeds contained less than 2 and 0.5 µg Æ9-THC/g seeds, respectively.
Fluctuations in the Æ9-THC content of different replicates of the same type
of seeds could be the result of the degree of contamination on the outside of
the seeds. Reproduction
of editorial content of this journal is prohibited without publisher’s
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